1. To identify patients preoperatively whose tumor type make them
candidates to provide residual tissue samples.
2. Obtain informed consent and associated primary information relating
to health behaviors, health
history and other exposures that may be important in the evaluation of
outcomes for the patient's
3. Obtain and store residual tissue samples from diagnostic specimens
plus a 3-5 cc sample of
blood. The residual sample must be obtained under conditions that:
a. maintain the integrity of the specimen for diagnosis and pathologic
b. Minimize degradative changes in RNA integrity and changes in gene
4. Maintain information concerning the stored residual sample and
selected clinical information in a coded database in a system separated
from the database containing patient identifiers.
5. Perform histological evaluation of residual specimens prior to
molecular analysis to ensure that
the specimen is, to the extent possible, homogeneous for either normal
or neoplastic tissue.